The objective of this research work was to formulate and evaluate of stomach specific chitosan based mucoadhesive microspheres of metoprolol tartrate by spray drying. The main drawback of metoprolol tartrate conventional dosage formulation are short biological half-life, its selective absorption form upper part of gastrointestinal tract, frequent administration and low oral bioavailability. By preparing chitosan based mucoadhesive microspheres of metoprolol tartrate, above drawbacks can be avoided. A 32 full factorial design was used for assessment of influence of two independent variable concentration of chitosan (X1) and polymer to drug ratio (X2) on the drug release at 6 hr (Y1) and 12 hr (Y2), % practical yield (Y3) and particle size (Y4). Mucoadhesive microspheres prepared by using spray drying because it gives better entrapment efficiency and small particle size with narrow particle size distribution. Microspheres was evaluated by various parameter with their results are entrapment efficiency (60.18-92.14%), mucoadhesion strength (68.8-83.9%), particle size (4.7-7.05 µm) and drug release at 12 hr (90.4-99.71%). Varying the concentration of chitosan and polymer to drug ratio have significant effect on response variables. Model validated by formulating the check point batch. No significant bias was found between predicted and observed value of check point batch. Short term stability study was carried out of optimized batch. The data of stability study revealed that the optimized formulation is stable. Hixon-Crowell model was fit to the drug release of optimized batch and its R2 value 0.9863.
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