Brucine is the active component in traditional Chinese medicine ââ?¬Å?Ma-Qian-Ziââ?¬Â (Strychnos nux-vomica Linn), with capabilities of\nanalgesic, anti-inflammatory, anti-tumor and so on. It is crucial how to break through the impact of cuticle skin which reduces\nthe penetration of drugs to improve drug transmission rate. The aim of this study is to improve the local drug concentration by\nusing ultrasound. We used fresh porcine skin to study the effects of ultrasound on the transdermal absorption of brucine under\nthe influence of various acoustic parameters, including frequency, amplitude and irradiation time.The transdermal conditions of\nyellow-green fluorescent nanoparticles and brucine in skin samples were observed by laser confocal microscopy and ultraviolet\nspectrophotometry. The results show that under ultrasonic conditions, the permeability of the skin to the fluorescent label\nand brucine (e.g., the depth and concentration of penetration) is increased compared to its passive diffusion permeability. The\nbest ultrasound penetration can make the penetration depth of more than 110 microns, fluorescent nanoparticles and brucine\nconcentration increased to 2-3 times. This work will provide supportive data on how the brucine is better used for transdermal\ndrug delivery (TDD).
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