In the present study, controlled release sertaconazole nitrate (SZN) microsponge gel for topical delivery was formulated and evaluated. Microsponges were prepared successfully using six different proportions of ethyl cellulose as a polymer, using PVA as surfactant by the quasi-emulsion solvent diffusion method. The influence of the drug to polymer ratio, surfactant concentration, inner phase volume and stirring speed on the drug entrapment efficiency and physical characteristics of the microsponges were investigated. Compatibility of the drug with adjuncts was investigated by FT-IR and DSC. SEM analysis was used to study surface morphology which showed spherical and spongy nature of microsponges. The particle size of the optimized formulations was in between 300-450 µm and the drug entrapment efficiency was in the range of 45.23 % to 91.49 %. These microsponge gel formulations were prepared using carbopol 934 and studied for pH, viscosity and in-vitro drug release. The batch G3 was considered to be optimal as it shown 71.23 % drug diffused within 24 hrs.
Loading....