The present work employed preparation of metaxalone nanocrystals (MNC) by emulsion solvent diffusion method using β-cyclodextrin (CD) as stabilizer. Nanocrystals were characterized for morphology by scanning electron microscopy, crystallinity by powder x-ray diffraction and particle size by zeta sizer. Solubility study of metaxalone (MTX) and MNC was performed in distilled water, 7.4 phosphate buffer and 0.1N Hydrochloric acid. Preparation of MNC in size range of 450-650 nm was done successfully. An inverse relationship between size and zeta was observed. Further 2 fold enhancement in aqueous solubility and elevated drug release profile for formulated nanocrystals was observed. In conclusion MNC prepared demonstrated to be a rising approach for enhancing the solubility and bioavailability of MTX.
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