There are several challenges involved in the development of effective anti-cancer drugs,\nincluding accurate drug delivery without toxic side effects. Possible systemic toxicity and the\nrapid biodegradation of drug carriers are potential risks in the use of carriers for drug-delivery\nformulations. Therefore, the carrier-free drug delivery of an anti-cancer drug is desirable. Herein,\n4-amino-2-benzyl-6-methylpyrimidine (ABMP) was synthesized via a new method using a sodium\ncatalyst, and proved to be effective in inducing breast cancer cell (MDA-MB-231) apoptosis. Moreover,\nthe transparent amorphous state solid of ABMP was demonstrated to have a slow-release property in\nphosphate buffer solution (PBS). Microspheres of ABMP were prepared with diameters in the range\nof 5ââ?¬â??15 Ã?¼m. The slow-release property of the ABMP microspheres indicated their potential use for\ncontrolled-release drug delivery. We believe that microspheres of ABMP have potential as a new kind\nof carrier-free anti-cancer drug delivery system.
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