We have synthesized hollow mesoporous silica (HMS) at a zeolitic imidazolate framework (ZIF) capsule that can be used as a drug\ndelivery system for gentamicin (GM). The GM is first loaded into HMS. Then, the outer surface of the GM/HMS is coated with\nuniformed ZIF nanoparticles (denoted as GM/HMS@ZIF). The GM/HMS@ZIF has been successfully prepared and acts as a\ncapsule for GM. The GM/HMS@ZIF shows a good biocompatibility and a good cellular uptake in House Ear Institute-Organ of\nCorti 1 (HEI-OC1) cells. The GM is released slowly within 10 h under acidic conditions, which is used to simulate the pH of the\nendosome and lysosome compartments. The in vivo assay shows that the signal from fluorescein isothiocyanate (FITC) can be\nobserved after 15 days, when the mice were injected with FITC/HMS@ZIF. This opens new opportunities to construct a delivery\nsystem for GM via one controlled low dose and sustained release for the therapy of M�©ni�¨reâ��s disease.
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