Cyclosporine (CsA) has a selective property of suppressing various T-lymphocyte functions.\nThis is of utmost importance in preventing allograft rejection by several organ transplantations,\nas well as in the treatment of systemic and local autoimmune disorders. However, the poor water\nsolubility of CsA can be a major hurdle for its absorption into the blood stream, which leads to low\nbioavailability and thus less efficacy. The aim of this study was to prepare, characterize, and evaluate\nin vitro as well as in vivo, the potential of the innovative CsA drug delivery system. The latter\ncontains CsA in spherical amorphous solid dispersion (SASD) which is embedded in an original.........
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