This paper introduces a new fibrous system for synergistic cancer therapy, which consists\nof gold nanocage (AuNC)-loaded poly caprolactone (PCL) fibers with encapsulation of a\nchemotherapeutic anticancer drug in their core and loading of a phase-changeable fatty acid in their\nsheath. Under on-off switching of near-infrared (NIR) light irradiation, the excellent photothermal\nability and photostability of AuNCs allows repeated, significant heating of the fibers to a temperature\navailable to hyperthermia. Simultaneously, the NIR light-induced heat generation enables the\nmelting out of the loaded fatty acid, leading to a rapid release of the drug molecules from the fibers.\nThe combination of this NIR light-triggered drug release with the repeated hyperthermia treatment\nexhibits excellent anticancer efficacy
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