Cancer remains a major threat to human health worldwide. Cytotoxicity has imposed\nrestrictions on the conventional cytotoxic drug-based chemotherapy. The rapidly-developing\nnanomedicine has shown great promise in revolutionizing chemotherapy with improved efficiency\nand reduced toxicity. Gd@C82(OH)22, a novel endohedral metallofullerenol, was first reported by\nour research group to suppress tumor growth and metastasis efficiently without obvious toxicity.\nGd@C82(OH)22 imprisons tumors by facilitating the formation of surrounding fibrous layers which is\ndifferent from chemotherapeutics that poison tumor cells. In this review, the authors first reported\nthe antineoplastic activity of metallofullerenol Gd@C82(OH)22 followed by further discussions\non its new anti-cancer molecular mechanism-tumor encaging. On this basis, the unparalleled\nadvantages of nanomedicine in the future drug design are discussed. The unique interaction modes\nof Gd@C82(OH)22 with specific targeted biomolecules may shed light on a new avenue for drug\ndesign. Depending on the surface characteristics of target biomolecules, nanomedicine, just like a\ntransformable and dynamic key, can self-assemble into suitable shapes to match several locks for the\nthermodynamic stability, suggesting the target-tailoring ability of nanomedicine.
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