The purpose of this work was to develop felodipine-loaded ethosomes to advance its therapeutic efficacy through transdermal delivery. Ethosomes (ES) were fabricated via a 31.21 mixed full factorial design, the factors considered were; phospholipid amount (200 mg and 300 mg), Felodipine amount (10 mg and 20 mg) and ethanol percentage (10% and 15 % v/v). All ethosomes were formulated with thin-film hydration method and characterized for their entrapment efficiency (EE). The optimized ethosomal formula (F-1) consisted of phospholipid (200 mg) and ethanol percentage (10%) and was subjected to morphological examination and in-vitro release study. Spherical vesicles with uniform particle size were displayed from the transmission electron microscopy. Also F-1 showed a superior release profile when compared to felodipine suspension. Consequently, ethosomes could be promising for an improved transdermal delivery of felodipine.
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