The aim of the present study was to develop and evaluate ethosomal gel containing neomycin sulphate to increase the drug permeation through the skin. The prepared ethosomal gels were also characterized for measurement of pH, spreadability, viscosity, drug content. The ethosomal gels were also evaluated for in-vitro drug release through cellophane membrane and the final best formulation was evaluated for ex-vivo permeation study through pig skin. Amongst all formulations, F6 formulation showed acceptable spreadibility, viscosity and pH value, with maximum entrapment efficiency (81.2%) with excipient concentration i.e. 2% phospholipid and 30% ethanol. The ideal vesicle size was achieved as 4069 nm, with zeta potential 1.36 mV with the PDI of 0.316. In-vitro permeation study showed a release of 89.98 g/cm2 in 8h and ex-vivo permeation studies showed a release of 80.11 g/cm2.
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