Recently, nanogels have been identified as innovative formulations for enlarging the\napplication of hydrogels (HGs) in the area of drug delivery or in diagnostic imaging. Nanogels are\nHGs-based aggregates with sizes in the range of nanometers and formulated in order to\nobtain injectable preparations. Regardless of the advantages oered by peptides in a hydrogel\npreparation, until now, only a few examples of peptide-based nanogels (PBNs) have been developed.\nHere, we describe the preparation of stable PBNs based on Fmoc-Phe-Phe-OH using three dierent\nmethods, namely water/oil emulsion (W/O), top-down, and nanogelling in water. The eect of the\nhydrophilicâ??lipophilic balance (HLB) in the formulation was also evaluated in terms of size and\nstability. The resulting nanogels were found to encapsulate the anticancer drug doxorubicin, chosen as\nthe model drug, with a drug loading comparable with those of the liposomes.
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