The aim of the study was to mask the bitter taste of fexofenadine HCl using Eudragit E100 and prepared the chewable tablet. The taste masked granules of fexofenadine HCl were prepared by wet granulation method using pH sensitive, cationic copolymer eudragit E100 and pre-gelatinized starch as disintegrant and prepared into chewable tablet. Central composite design (CCD) was applied as an optimization technique. As eudragit E100 is soluble at pH below 5, the dissolution was assessed using USP dissolution apparatus-II in 0.001 N HCl (pH 1.2) simulated gastric fluid was chosen as the dissolution medium. FTIR and DSC studies indicated that drug and excipients were compatible with each other. The key attributes i.e. hardness, dissolution and disintegration test was performed successfully. The optimized batch FH1 passes all the pre-compression and post-compression parameters and it was given as best by CCD. Taste-masking evaluation was done successfully. Disintegration time was obtained 16 min. The % drug released was found to be 99.40% within 60 min. It was concluded that the aim of taste masking of fexofenadine HCl using eudragit E100 and formulated into chewable tablet by wet granulation method was successfully achieved.
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