Technological advancements have developed several novel approaches for the delivery of various types of drugs that could revolutionize the methods of medication and provide a number of therapeutic benefits. Oral controlled drug delivery forms a crucial facet among novel drug delivery systems. Rational approach to enhance bioavailability and improve pharmacokinetic and pharmacodynamic profile of orally administered drug is to retain the drug reservoir above its absorption area i.e. in the stomach and to release the drug in a controlled manner, so as to achieve zero order kinetics (i.e. oral infusion) for a prolong period of time. One such approach of oral sustained drug delivery which has gained attention of academic and industrial research group is gastro-retentive drug delivery system (GRDDS). The focus of this review is to give the detail insight of various formulation approaches used in GRDDS.
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