In this work we describe the relationship between surface modification of\nhexagonally ordered mesoporous silica SBA-15 and loading/release characteristics of nonsteroidal\nanti-inflammatory drug (NSAID) naproxen. Mesoporous silica (MPS) was modified with\n3-aminopropyl, phenyl and cyclohexyl groups by grafting method. Naproxen was adsorbed into pores\nof the prepared MPS from ethanol solution using a solvent evaporation method. The release of the\ndrug was performed in buffer medium at pH 2 and physiological solution at pH 7.4. Parent MPSs as\nwell as naproxen loaded MPSs were characterized using physicochemical techniques such as nitrogen\nadsorption/desorption, thermogravimetric analysis (TG), Zeta potential analysis, Fourier transform\ninfrared spectroscopy (FT-IR), and elemental analysis. The amount of naproxen released from the\nMPSs into the medium was determined by high-performance liquid chromatography (HPLC). It was\nshown that the adsorption and desorption characteristics of naproxen are dependent on the pH of the\nsolution and the surface functionalization of the host
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