The purpose of this study was to prepare lipospheres drug delivery system for anti diabetic drug repaglinide with the aim of exploiting the favorable properties of this carrier system and developing a sustained release formula to defeat the side effects. Lipospheres using different ratio of bees wax, stearic acid, cetyl alcohol, tween 80 and phospholipids coat such as soybean phosphotidylcholine in various concentration was prepared in order to obtain new formulation containing repaglinide to reduce blood glucose level. Seven different formulations of lipospheres were prepared by melt dispersion technique. Lipospheres thus prepared were characterized for particle size, scanning electron microscopy, % entrapment efficiency, % yield, % drug content, in-vitro drug release and stability study. All the formulation gave the satisfactory result in terms of particle size, entrapment efficiency and drug content. Lipospheres were substantially stable after 3 months storage at 2–8°C. Repaglinide release from the lipospheres was depended on the ratio and type of the polymer used in the formulation. The best lipospheres performance and in-vitro drug release profile were achieved by using repaglinide, stearic acid and bees wax i.e. F4 formulation, this formulation shows drug release of 80.6±1.50 % at the end of 12 h.
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