In recent years scientific and technological advances have been made in development of ocular controlled drug delivery system (OCDDS) to overcome physiological adversities such as short residency time, rapid elimination of drug, lower bioavailability of drug. The present investigation was focused to prepare resinate of drug (moxifloxacin) and ion exchange resign (INDION 254) to increase the residence time and decrease the solubility of drug in ocular site and incorporated in ocular insert. Ocular insert was prepared by solvent casting method. Nine formulations of OCDDS were prepared with different concentration of polymer (HPMC, MC, and PVA). Prepared formulation was subjected to physicochemical evaluation test like thickness, surface pH, swelling index, folding endurance, In vivorelease test, antimicrobial test, sterility test, In vivo release and accelerated stability study test. In vivorelease of formulation BRF6 was shown 98.87 % at the end of 12th hrs. In vivorelease of all the formulation was computed with release kinetic model to predict release rate. Higuchi matrix model suggested all the formulation was followed diffusion release mechanism. Korsmeyer Peppa’s equation suggested that all formulation was followed anomalous diffusion mechanism. Optimized formulation (BRF6) was subjected to antimicrobial test and sterility test. Result clearly showed it was passed. Accelerated stability study indicated optimized formulation was stable for longer period of time.
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