The ultimate goal of any drug delivery system is the successful delivery of the drug to the body; however, patient compliance must not be overlooked. Fast dissolving oral drug delivery systems, such as, fast dissolving oral films, offer a convenient way of dosing medications, not only to special population groups with swallowing difficulties such as pediatric and geriatric patients, but also to the general population. Fast dissolving oral Films are the novel dosage forms that disintegrate and dissolve within the oral cavity within a minute, without needing water or chewing. A novel fast release oral film drug delivery system for the treatment of emesis in pediatrics and geriatric patients was developed for immediate oral delivery of Domperidone which is an excellent antiemetic drug. Domperidone films were prepared by solvent casting technique using two water soluble polymers, Pullulan and Sodium carboxy methyl cellulose in different concentration. Infrared analysis revealed no interaction between Domperidone and polymers. The prepared films were evaluated for their thickness uniformity, folding endurance, content uniformity, surface pH, In-vitro disintegration time and In-vitro drug release. Formulation F1 released 99.27% of drug within 12 sec and was considered as best formulation. This case study showed that Pullulan was the most suitable film-forming material for domperidone-loaded films, providing fast dissolution films that were not sticky and were easy to handle.
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