Pectin pellet loaded with highly hydrophilic drug, levetiracetam were prepared by powder layering technique. Pectin and starch powder was used as release retarding material. Eudragit L100 and S100 were act as the shell material. Both, the powder mixture and drug was sieved through a 400 µm screen and mixed with Polyvinyl pyrolidone (kollidon 25) in water as binder. The resultant pellets by this technique were evaluated for physiochemical properties like micromeritic properties, particle size, percentage yield, sphericity index, entrapment efficiency, % mucoadhesion, drug release pattern, scanning electron microscopy, release kinetics and stability. The pellet size measured by sieving method was ranged from 699.11-840.9µm. The enhancement of pectin content in pellet resulted in increasing pellet size. From the study it was found that formulation containing middle level polymer ratio had high % yield and encapsulation efficiency. Percentage mucoadhesion were increased from 57 % to 82 % due to increases of pectin. The drug release study was performed using USP XXIV basket apparatus. The study of drug release showed that in SGF % release of drug was found to be less for all formulations. In SIF, at the end of 6th h release rate was 36.03 ± 1.05% for LPP1 and 22.05 ± 0.66% for LPP4. In SCF, at the 8th h the release was 102.15 ± 0.30% for LPP1. In conclusion, pectin pellet loaded with levetiracetam obtained with desirable size, shape, % yield, sphericity index, entrapment efficiency and drug release profile.
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