The purpose of this research was to formulate and systematically evaluate In vitro performances of biodegradable microspheres of Metformin HCl, an oral hypoglycemic agent for treatment of Type-II diabetes. The present study consisted of a three-level three-factorial (33) design- Box Behnken design for experimentation. A 3-factor, 3-level Box-Behnken design was used to derive a second order polynomial equation and construct contour plots to predict responses. Response surface graphics were used to show the factor interaction between the considered variables. Selected independent variables studied were the Drug: Polymer Ratio (X1); Agitation Speed (rpm) (X2); and Surfactant Ratio (X3) added to the formulation. The selected dependent variables investigated were particle size (μm), percentage drug entrapment efficiency and percentage of drug released at 12 hrs. Batch P1 exhibited excellent results in terms of particle size (32.78μm), percentage drug entrapment efficiency (75.25) and percentage of drug released (82.24) at 12 hrs.
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