The aim of present work was to formulate Mucoadhesive buccal patches of Omeprazole .The buccal region of the oral cavity is an attractive target for administration of the drug of Choice for increase bioavailability and prevent first pass metabolism of drug and also to prevent degradation in stomach. Omeprazole patches were prepared using HPMC K15 M, HPMC K4M, PVP K30, Sodium Alginate, Eudragit L 100, Eudragit S100 and Carbopol 934. The patches were evaluated for their thickness, Uniformity content, folding endurance, weight uniformity, Swelling index, tensile strength and surface pH. In vitro loaded studies of Omeprazole was done in phosphate buffer (pH 6.8).
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