The present work was aimed at formulating a solid dosage form system (tablets) for Trimetazidine dihydrochloride (TDH) using the principles of osmosis which will bring down its dosing frequency to once a day and at the same time produce a zero-order release system. A monolayer osmotic tablet was formulated by coating the core tablet (containing 60 mg of drug and osmogen) with a semi permeable membrane to permit the penetration of water and drilling an orifice which would permit the release of drug after development of suitable osmotic pressure. For formulating a monolayer osmotic tablet, initially core and coating feasibility trials were carried out to select the best formulation for optimization study. Optimization study of HPMC K4M, Carbopol 71G, Osmogen (Mannitol and sodium chloride) and coating composition was done by varying the proportion of each in various formulations (MT1 to MT20) and analysing the release profile kinetics. Comparison of the release profiles of each formulations was made with the theoretically calculated target release profile using the f1 (Difference Factor) and f2 (Similarity factor). Formulation MT20 was selected as the final optimized formulation for monolayer osmotic drug delivery system. It showed an almost perfect zero order release (r2 = 0.995) and almost 100 % release after 24 hours.
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