The purpose of this study was to investigate microemulsion-based hydrogel (MBH) as a topical delivery system for acyclovir. Topical delivery of acyclovir in the forms of microemulsion, MBH and the commercial cream was evaluated in-vitro and in-vivo. The results of permeation test in-vivo in mice showed that compared with the commercial cream, MBH and microemulsion could significantly increase the permeation of acyclovir into both epidermis and dermis. Stability test showed that MBH stored at 4°C for 3 months had no significant change in physicochemical properties. Skin irritation test in rabbit demonstrated that single application or multiple applications of MBH did not cause any erythema or edema, slight skin irritation for microemulsion. Microstructure changes of skins after administration observed under light microscope and scanning electron microscope (SEM) might result from the interaction of the ingredients of microemulsion with skins, which was related with the permeation enhancement of acyclovir. It can be concluded that the MBH could be a promising vehicle for topical delivery of acyclovir.
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