Skin is the largest organ of the body and protects from physical, chemical and biological grievance. It acts as barrier for permeation especially for hydrophilic and ionic drugs due to the lipophilic nature of the stratum corneum. Iontophoresis offers transfer of the molecules from stratum corneum to the systemic circulation by the application of the tolerable electricity. Iontophoresis provides pulsatile delivery of drug and avoids first pass metabolism of drug. The present review covers advantages, disadvantages and criteria of the drug selection for iontophoresis. This review also focuses on the principle and mechanism of iontophoresis. Pathways for iontophoretic transfer and iontophoretic devices are also included in this review. This review gives idea about factors affecting iontophoresis and conjugation of iontophoresis with other techniques. Formulation method used for the iontophoresis and in-vitro iontophoresis study are also covered.
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