The main objective of this article is to focus on advancement in niosomal technology and its applications. Niosomes are novel and targeted drug delivery carriers and are the area of major interest of modern pharmaceutical research. Various vesicular systems such as liposomes, niosomes, transferosomes, erythrosomes, pharmacosomes and ethosomes have been used to improve the drug delivery. Niosomes play an increasing important role in drug delivery to the target as they can reduce toxicity and modifying pharmacokinetic and bioavailability and improve therapeutic performance. Niosomes are non ionic surfactant vesicles, obtained by hydration of thin film formed from mixture of cholesterol and non ionic surfactants that reduce the toxicity problem associated with other vesicular systems. They are multilamellar and unilamellar vesicles based on the method of preparation. The aim of this article is to review recent trends undertaken to develop niosomes carrier and combination of the niosomal technology with the in situ gelling technology to provide control and sustained delivery of drugs.
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