In the present study matrix and triple layer matrix tablets of Isosorbide Mononitrate (ISMN were formulated by using guar gum as the matrix forming agent and Sodium Carboxy Methyl Cellulose (SCMC) as barrier layers. The prepared tablets were analyzed for their hardness, friability, drug content and in vitro drug release studies. Marked differences in dissolution characteristics of (I3) and (I3L3) were observed and showed a significant difference statistically. Mean dissolution time (MDT) for I3 and I3L3 were found to be 4.61h and 12.76h, while dissolution efficiency (DE8%) decreased, indicating that the release of ISMN is slower from triple layered matrix tablets. The finding of the study indicated that the matrix tablets prolonged the release, but predominantly in a first order kinetics. Layering with SCMC granules on the matrix core, provided linear drug release with zero order kinetics. The triple layered matrix tablets (I3L3) shows precise controlled release of the drug than that of plain matrix tablets (I3). FT-IR and DSC studies confirmed that there was no chemical interaction between drug and excipients used in the formulation.
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