The present work aimed at testing the ability of buccal transmucosal drug delivery to provide rapid onset of action compared to other routes. Tramadol an opoid analgesic indicated in severe painful conditions if given by such route may enhance patient compliance. Buccal patch was selected for present study. Bioadhesive buccal patch of tramadol was prepared using various polymers. This patch was evaluated for pharmacokinetics in rabbit and amount of drug absorbed was analysed by HPLC (High performance liquid chromatography) method and compared in-vivo with available marketed oral tablets of tramadol. It was observed that tmax of buccal patch was 30 minutes i.e. drug release from patch and absorption into systemic circulation was faster compared to oral delivery of tramadol via tablets which had tmax of 2 hours.
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