The aim of the present study is to design and develop a bilayered gastro retentive tablets containing Glipizide and Metformin hydrochloride by using a natural gum for the effective usage of diabetes disorders. The compatibility studies were confirmed by I.R spectral studies. Different bilayered floating tablets were formulated using Glipizide in the immediate release layer and Metformin hydrochloride in the sustained release layer by direct compression method. The weight variation, friability, hardness, swelling index and drug content of the tablets were found to be satisfactory. The release pattern for all the formulations followed zero order kinetics and ascertained peppas mechanism, further it was observed that the release profile from the gum kondagogu (grade-2) was governed by predominant non fickian diffusion (p>0.5). Of all the formulations, the formulation F5 was considered as the best formulation since it produced 93.04%of the Glipizide drug release at the end of 25 minutes and 97.44% of Metformin hydrochloride at the end of 12 hours. The individual layer assessment in the floating bilayered tablet indicated that there was no severe impact of Metformin hydrochloride on Glipizide leading to toxic effects well maintaining the therapeutic levels with Glipizide activity on the excess blood sugar levels .In vivo radiographic images of rabbits abdomen on F5 revealed that the tablets floated within 10 minutes and the gastric residence time was found to be more than 10 hours. The results suggested that the gum kondagogu act as a natural release retarding agent further indicating their floating nature.
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