The aim of present study is to formulations of NLC loaded nanoparticles for treatment of patients with psoriasis. This novel formulation of Halobetasol Propionate was prepared by using both solid lipid and liquid lipid with different concentration of surfactant by high pressure homogenization method.NLC were characterized for particle size, polydispersity index (PDI), zeta potential, entrapment efficiency and In vitro release. Surface morphology was determined by Scanning electron Microscopy (SEM). NLC based gel was characterized for pH, Spredability, drug content, stability study. Stability study was carried out for 3 month. It indicated no significant change in particle size, Zeta Potential, PDI, drug content and drug release. \r\nKeywords: Halobetasol propionate, psoriasis, NLC etc.
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