The aim of this study was to development and characterize press coated tablet of Diacerein and Aceclofenac. The drug delivery system was based on the concept of chronotherapeutics. Dosage form provides delayed release up to 6 h and after completion of lag time up to 6 h dosage form provides burst release of drugs therefore highest blood level of the drugs coincide with pain which occurs particularly at specific period of time during day cycle Drug polymer compatibility studies were carried out by FT-IR. If one drug is act as DMARD (Disease Modifying Anti Rheumatic Drug) and other drug act as NSAID ( Non Steroidal Anti Inflammatory Drug) this combination has well established effect on arthritis. Here, Diacerein act as DMARD and Aceclofenac act as NSAID therefore Diacerein and Aceclofenac combination has been used for obtaining synergistic effect on treatment of arthrities. Core tablet was prepared by direct compression using superdisintegrants sodium starch glycolate. The core tablet was compression coated with different quantities of coating material containing different polymers. A 32 Full factorial design was used for optimization of barrier layer. Total coat weight (X1) and % HPMC K4M (X2) were selected as independent variables. The lag time for Diacerein (Y1), CPR at 1 st hr after lagtime for Diacerein (Y2), time for 90% drug release for Diacerein (Y3), the lag time for Aceclofenac (Y4), CPR at 1st hr after lagtime for Aceclofenac (Y5) and time for 90% drug release for Aceclofenac (Y6) were selected as dependent variables. Tablets were evaluated for various evaluation parameters. Comparative dissolution profiles of all the batches indicate drug release from tablet was inversely proportional to coat weight. From release profile it also found that delay lag time was observed for the press-coated tablet containing a higher amount of HPMC K4M in the outer shell. The press coated tablets coated with HPMC K4M:HPMC K100 in 64.39:35.61 ratios with 200 mg coat weight are most likely to provide desired delivery of Diacerein and Aceclofenac.
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