As drug delivery systems Nanoparticles are widely investigated because of many advantages such as smaller size, controlled drug release potential, targeting ability, enhancement of therapeutic efficacy and reduction of toxicity. This article describes the development of solid lipid nanoparticles (SLN) as colloidal carriers for Nifedipine. Nifedipine is an antihypertensive drug with poor oral bioavailability ranging about 10 to 20% due to first pass metabolism. The present study was undertaken to investigate the lipid nature of Dynasan-116 (Tripalmitin) on Nifedipine loaded solid lipid nanoparticles using hot homogenization ultrasonication method. Poloxamer-188 was used as surfactant. The prepared SLNs were characterized for particle size, polydispersity index (PDI), zeta potential, entrapment efficiency (EE) and invitro drug release studies. The invitro characterization of nifedipine loaded SLN was performed in 0.1NHCl and pH6.8 phosphate buffer using dialysis bag method. Differential Scanning Calorimetry (DSC) studies were conducted to characterize the state of drug and lipid modification.
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