The objective of the present research work was formulation and evaluation of sublingual film containing nanoparticles of prochlorperazine maleate to get quick disintegration for rapid release and onset of action in the treatment of chemotherapy induced nausea and vomiting. For dissolution rate enhancement, nanosuspension of prochlorperazine maleate was prepared using high speed homogenizer. This nanosuspension was casted in the petridish. HPMC E 5-LV and SDS were used as a stabilizer in nanosuspension. HPMC E 5-LV used as film forming polymer and PEG 400 used as a plasticizer. Nanosuspensions were evaluated for parameters like particle size, PdI and zeta potential. Sublingual films were evaluated for physical characterizations, thickness, surface pH, disintegration time, tensile strength, folding endurance, drug content, in-vitro drug release, ex-vivo permeation study and taste masking study. In this research, release profile depends on the concentration HPMC E-5 LV. 32 factorial design was applied to check the effect of concentration of HPMC E-5 LV (X1) and PEG 400 (X2) on the dependent variable i.e. % in-vitro drug release Y1, disintegration time (sec) Y2 and tensile strength Y3. ANOVA was performed for dependent variables. From D.O.E 9.0.1 software F5 concluded as optimized batch which contains HPMC E 5-LV (250 mg) and PEG 400 (20% w/w of HPMC E 5-LV). The studies indicating that dissolution rate increase by film containing nanoparticle of drug and quick disintegrating film can efficiently be formulated of prochlorperazine maleate by using solvent casting technique.
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