Gastroretentive drug delivery systems have shown to be of better significance in controlling release rate for drug having site specific absorption. The purpose study was to develop an optimized dual retard floating tablet of amlodipine besylate and atenolol using optimization technique. Dual retard floating tablet comprised of two layers, i.e immediate release layer of amlodipine besylate and sustained release layer of atenolol. Immediate release layer comprised of different superdisintegrant like sodium starch glycolate, cross carmellose sodium and kyron T-314. Formulation containing 4% Kyron T-314 as a superdisintegrating agent was selected as optimized formulation which release 99.86% of amlodipine besylate within 30 min. Sustained release layer comprised of different polymers like HPMC K4m, HPMC K15M and HPMC K100M. Formulation containing 10% HPMC K100M was selected as optimized which release 90% of drug within 12 hours. Gas generating approach was used for floating purpose. A 32 factorial design was employed in formulating the GRFDDS with conc. of HPMC K100M (X1) and sodium bicarbonate (X2) as independent variables while xanthan gum was added to maintain matrix integrity. FLT, Q15, T50, T75 and Q360 were selected as dependent variables. The granules were characterized by FTIR and DSC studies. There was no incompatibility observed between them. There was no significant change observed after following ICH stability guideline.
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