Pharmaceutical research and invention started focusing increasingly on delivery systems which enhance desirable therapeutic objectives minimizing the side effects. Multiparticulate drug delivery system (MDDS) is composed of small beads and each small bead further composed of many layers of drug substance and rate-controlling polymers. Recent trends suggest that MDDS are especially suitable for achieving controlled or delayed release with low risk of dose dumping, reproducible, flexibility of blending to attain different release patterns as well as short gastric residence time. The various release profiles like sustained release, time delayed release, and pulsatile release of active pharmaceutical ingredients can be achieved using this approach. The duration of drug release following the lag time depends on the composition and thickness of the polymer barrier and the coating itself. The multiparticulate system provides optimal release profiles for either single drug or for a combination of drugs. Consequently, multiparticulate drug delivery systems provide tremendous opportunities for designing new controlled and delayed release oral formulations, thus extending the frontier for future pharmaceutical development. The present review is an attempt to give the detail insight of various designs and technologies which have been tried in the formulation of MDDS.
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