The occurrence of antimicrobials in the aquatic environment and drinking water has raised the\nquestion of their impact on the environment and public health. Animal production is one of the\nmost expressive activities of Brazilian agribusiness. In order to ensure the productivity and\ncompetitiveness of the sector, the use of drugs for therapeutic and prophylactic purposes is a\ncommon practice. Due to the continuous release of antimicrobials into the environment, the aim\nof this study was to compare the frequency of detection of tetracyclines and sulfonamides in\nsurface water collected from rural areas in Lidice District of Rio Claro, in the State of Rio de Janeiro,\nBrazil. An investigative study was conducted with 24 river water samples analyzed by\nhigh-performance liquid chromatography coupled to tandem mass spectrometry and the aim of\nthis study was to determine residues of sulfonamides and tetracyclines based on the USEPA method\n1694. The results indicated the presence of sulfamethoxazole and oxytetracycline concentrations\nat the ngâË?â?¢LâË?â??1 level. The applied method showed overall good performance with recoveries\nabove 57%, method detection limits ââ?°Â¤ 7.17 ngâË?â?¢LâË?â??1, method quantification limits ââ?°Â¤ 23.90\nngâË?â?¢LâË?â??1 and good linearity.
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