The present study has examined the antibacterial activity of Euphorbia granulata Forssk aerial parts ethanolic extract using agar disc diffusion method against some Gram-positive and Gram-negative bacteria (Pseudomonas aeruginosa, Listeria monocytogenes, Staphylococcus epidermidis, Staphylococcus aureus, Klebsiella pneumoniae, Salmonella Typhi, Bacillus cereus, Bacillus anthracis, Escherichia coli and Streptococcus pyogenes). This extract had inhibitory effect at different concentrations (0.05, 0.1, 0.2 and 0.4 g ml-1) against above mentioned bacteria. P. aeruginosa and E. coli were the most resistant strains. The highest inhibitory activity of the ethanolic extract (32 mm) was found against S. epidermidis, while the lowest inhibition (7 mm) was demonstrated for B. cereus and L. monocytogenes. The extract exhibited Minimal Inhibitory Concentration (MIC) at 5 mg ml-1 against S. epidermidis and S. aureus, while its Minimal Bactericidal Concentration (MBC) was 5 mg ml-1 and 10 mg ml-1 against S. epidermidis and S. aureus, respectively. Consequently, E. granulata could be as a new source for antibiotic discovery and infection treatment.
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