Seeds of Coriandrum sativum have been used in the Indian traditional medicine to relieve stress and other neurological disease conditions. The present study was under taken to evaluate the antidepressant and anxiolytic effects of seeds of Coriandrum sativum Ethanolic Extract (CSEE) in mice. Seeds of Coriandrum sativum ethanolic extract were screened for antidepressant effect by using forced swim test and anxiolytic effect by using locomotor activity at doses of 100 and 200 mg/kg. Distilled water and diazepam were employed as negative and positive control groups, respectively. Antidepressant activity assessment of seeds of Coriandrum sativum ethanolic extract (CSEE) 200 mg/kg shows significantly decrease in immobility time (70.96%) as compared to standard (58.70%) treatment group. While anxiolytic like activity assessment of seeds of Coriandrum sativum ethanolic extract (CSEE) 200 mg/kg shows significantly decrease in locomotion (59.64%) as compared to standard (33.92%) treatment group. The results of this study established a support for the traditional usage of seeds of Coriandrum sativum as antidepressant and anxiolytic medicinal plant.
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