Inflammatory bowel disease (IBD) is a spectrum of chronic idiopathic inflammatory intestinal conditions. The aim of present investigation was to evaluate the effect of alcoholic extract of Plectranthus amboinicus in indomethacin induced enterocolitis and acetic acid-induced colitis models of IBD in wistar albino rats. Two doses 200 mg/kg and 400 mg/kg b.w p.o of the Plectranthus amboinicus extract were subjected for the evaluation of treatment of IBD activity against the IBD induced by indomethacin (7.5 mg/kg, s.c) and acetic acid (2 ml 4% intrarectally) in rats. Prednisolone, 2 mg/kg, p.o was served as standard in both the models. The parameters studied includes measurement of physical parameters; change in body weight and colon weight, estimation of biochemical parameter; myeloperoxide and lipid peroxides, macroscopic evaluation; scoring of ulcers and microscopic evaluation; histopathology. The pretreatment with alcoholic extract of Plectranthus amboinicus at a dose of 200 and 400 mg/kg, p.o. and standard group of animals significantly (P < 0.01 and P < 0.001 respectively) and dose dependently attenuated results in all above said parameters when compared to disease inducing group. Histopathological study supports the above results by protective and regeneration effects on colonic cells by Plectranthus amboinicus pretreatment. The results obtained were comparable with that of the standard.
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