The objective of this study was to investigate the hepatoprotective activity of ethanolic extract of stem bark of\nDesmodium oojeinense (Roxb.). H. Ohashi against carbon-tetrachloride induced hepatotoxicity in wistar rats. The\nhepatoprotective activity of the ethanolic extract was assessed in CCl4 induced hepatotoxic rats. Alteration in the levels of\nbiochemical markers of hepatic damage like SGOT, SGPT, ALP and total bilirubin were tested in both CCl4 treated and untreated\ngroups. CCl4 has enhanced the SGOT, SGPT, ALP and total bilirubin in liver. Treatment with ethanolic extract of Desmodium\noojeinense has brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner.\nResults of histopathological studies also provided supportive evidence for biochemical analysis. Silymarin (100 mg/kg) was\ngiven as a standard hepatoprotective drug. Our findings suggested that the ethanolic extract of stem bark of Desmodium\noojeinense (Roxb.). H. Ohashi possesses the hepatoprotective activity.
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