Erythrina variegata Linn of the family leguminaceae is a medium sized deciduous small tree. The leaves are used in fever, inflammation and joint pain. The juice of the leaves is used in earache, toothache, constipation, cough, and also known to stimulate lactation and menstruation. Different parts of E.Variegata have used in traditional medicine as nervine sedative, febrifuge, anti-asthmatic and antiepileptic. This study was under taken to evaluate the local anesthetic activity of the aqueous extract of E.variegata by plexus anesthesia in frogs. The mean onsets of anaesthesia were found with the test drug was 6.67 ± 0.33 min compared to 2.75 ± 0.33 min for the standard drug in plexus anesthesia model. The results revealed the significant local anesthetic activity with the control group.
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