Methanol extracts and fractions of Melia azedarach (A. Juss) and Khaya senegalensis (Ders) A. Juss stem bark and leaf (Meliaceae) was evaluated on the larvae of Anopheles gambiae the principal malaria vector for toxicity and growth inhibition. Out of the four crude methanol extracts screened the leaf of M. azedarach and stem bark of K. senegalensis were toxic to the larva. The hexane soluble fraction of M. azedarach displayed absolute mortality at 0.625 mg/mL with an LC50 value of 0.025 mg/mL; likewise hexane soluble fraction of K. senegalensis was less active on larva with an LC50 value of 0.081 mg/mL. The hexane fractions of both plants displayed overwhelming activities compared with the reference compound N, N-Diethyl-m-toluamid (DEET) which had an LC50 of value of 1.09 mg/mL. Larval exposed to M. azedarach extract did not develop into pupa. On the other hand, development was minimal when exposed to K. senegalensis extract.
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