Background. Diarrhea is one of the leading causes of preventable death in developing countries and mainly affects children and\ninfants. It has been reported that the leaf of Justicia schimperiana is used as an antidiarrheal agent in Libo Kemekem district,\nnorthwest Ethiopia. Method. The 80% methanolic leaf extract of J. schimperiana was evaluated for its activity against castor oilinduced\ndiarrhea, enteropooling, and gastrointestinal motility in mice. Results. Significant reduction (
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