Hyperlipidemia is a disorder of lipid metabolism manifested by elevation of plasma concentrations of the various lipid and lipoprotein fractions, which is the key risk factor for cardiovascular disorders (CVD). Since synthetic drugs have been shown to have side effects, clinical importance of the herbal drugs in treatment of hyperlipidemia has received considerable attention in recent years. Capparis Deciduas F., Ricinus Communis L., and Zizyphus Jujuba L. are traditionally used as antihyperlipidemic drugs as per ayurvedic literature .Hence the present study was undertaken to investigate the antihyperlipidemic effect of a polyherbal formulation, prepared using the above three medicinal plants against Triton WR-1339 and High fat diet induced hyperlipidemia in rats. Hydroalcoholic extract of the polyherbal formulation at 200 and 400 mg/kg dose inhibited the elevation of serum and liver cholesterol and triglyceride levels in hyperlipidemic rats. The extract also significantly decreased 3-hydroxy-3-methylglutaryl- CoA reductase (HMG-CoA reductase) activity. Thus the hydroalcoholic extract of polyherbal formulation at the dose of 200mg/kg and 400mg/kg; p.o. showed good antihyperlipidemic activity in Triton WR-1339 and High cholesterol diet induced hyperlipidemic rats. The probable mechanism of action of the extract may be inhibition of HMG-CoA reductase enzyme pathway.
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