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Inventi Impact: Ethnopharmacology

Articles

  • Inventi:pep/44619/22
    Extraction and Fractionation of Bioactives from Dipsacus fullonum L. Leaves and Evaluation of Their Anti-Borrelia Activity
    01-Apr-2022 Research 2022 : April-June
    Piret Saar-Reismaa, Olga Bragina, Maria Kuhtinskaja, Indrek Reile, Pille-Riin Laanet, Maria Kulp, Merike Vaher

    Lyme disease (LD) is a tick-borne bacterial disease that is caused by Borrelia burgdorferi. Although acute LD is treated with antibiotics, it can develop into relapsing chronic form caused by latent forms of B. burgdorferi. This leads to the search for phytochemicals against resistant LD. Therefore, this study aimed to evaluate the activity of Dipsacus fullonum L. leaves extract (DE) and its fractions against stationary phase B. burgdorferi in vitro. DE showed high activity against stationary phase B. burgdorferi (residual viability 19.8 ± 4.7%); however, it exhibited a noticeable cytotoxicity on NIH cells................

    How to Cite this Article
    Attribution/ CC Compliant Citation: Saar-Reismaa, Piret, et al. "Extraction and Fractionation of Bioactives from Dipsacus fullonum L. Leaves and Evaluation of Their Anti-Borrelia Activity." Pharmaceuticals 15.1 (2022): 87. https://doi.org/10.3390/ph15010087 http://creativecommons.org/licenses/by/4.0/ Some formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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