The root bark of V. madraspatana is used in traditional medicine for the treatment of liver disorders. In this study the rats were divided into five groups, control group, negative control (carbontetrachloride), extract treated groups at dose of 200mg/kg and 400mg/kg and a standard treated group. Hepatoprotective activity of aqueous extract of Ventilago madraspatana root- bark on CCl4 induced damage in rats was investigated by estimating the biochemical parameter in both serum and liver of extract treated group. The extract treated groups showed significant decrease in serum glutamic oxaloacetate transaminase (SGOT), serum glutamic pyruvate transaminase, alkaline phosphatase (ALP), total bilirubin and increase in total protein. The liver homogenate of extract treated group showed decrease in total protein and inhibited lipid peroxidation (LPO) and increased the levels of glutathione peroxidase(GPx),glutathione-s-transferase(GST),glutathionereductase(GRD),superoxide dismutase (SOD), catalase (CAT) and vitamin E level . Histopathological studies of rats treated with aqueous extract of Ventilago madraspatana root bark reveals reduced cellular damage induced by CCl4. The results of present study suggest aqueous extract of Ventilago madraspatana root bark protects CCl4 induced chronic hepatotoxicity in rats by restoring the antioxidant status.
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