Triguna makaradhwaja (TM) a metalo-mineral drug was evaluated for anti-diabetic activity in Streptozotocin induced diabetes mellitus. Thirty adult Wister stain albino rats of either sex weighing between 180±20 g were selected and made diabetic by injecting Streptozotocin. The diabetic rats were divided into five groups, having 6 animals in each group. Triguna makaradhwaja along with Guduchi Ghana and honey administered at the dose of 3.15 mg/kg for 21 consecutive days. Glibenclamide was used as standard anti-diabetic drug. Parameters like effect on body weight, weight of liver and kidney, blood sugar level, serum cholesterol, serum triglyceride, HDL cholesterol; S.G.P.T. and S.G.O.T. activity, alkaline phosphates activity and Glycosylated hemoglobin, cytoarchitecture of pancreas, liver and kidney were studied. Treatment with test gradually decreased blood sugar level in 21 days treatment. It also produced moderate protection of pancreas and marked protection of liver and kidney against the toxicant. This study shows Triguna makaradhwaja is having moderate anti-diabetic activity.
Loading....