The antioxidant potential of polyherbal compounds namely, immuplus was assessed for therapeutic management of an experimental model of oxidative stress induced by ochratoxin, at a toxic level of 2.5 ppm in feed. A total of seventy five sexed male broiler chicks (Cobb strain) of day old age were procured for the study. The chicks were randomly divided into five groups consisting of fifteen in each group. Group 1 received normal basal diet from day 1 to 42nd day. Group 2 received Immuplus@ 75 mg/15 birds for 1–4 weeks, 150 mg/15 birds for 5–6 weeks. Group 3 was given Ochratoxin@ 2.5 ppm in feed for 42 days. Group 4 was given Ochratoxin@ 2.5 ppm for first 28 days followed by basal diet from 29–42 days. Group 5 birds received combination of ocharatoxin@ 2.5 ppm upto 42 days from day one and Immuplus@ 75 mg/15 birds for 1–4 weeks, 150 mg/15 birds for 5–6 weeks. Antioxidant defense profile (GSH-Px, GSH-R, catalase) was evaluated in blood and GSH, and TBARS was evaluated in liver. Serum parameters like ALT, BUN and total protein were evaluated as biomarkers of hepatic damage and kidney damage. Antioxidant enzyme levels and biochemical parameters were significantly altered in the ochratoxin toxic control groups. These parameters were normal in the controls (groups 1 and 2 and group 5 that was given immuplus therapeutically.
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