Therapeutic usage of some of the Indian herbal medicinal plants for fibrinolytic activity or thrombolytic activity in reducing the incidences of infarction is well known. Present study was carried out to investigate fibrinolytic activity of selected indigenous plants and culinary spices by determining the in-vitro clot lysis potential taking activity of urokinase, a known fibrinolytic enzyme as positive control. Experiments for clot lysis were carried out as described by Prasad(1), et al., (2006) with few modifications. Among the indigenous plants based on the percentage of clot lysis, Gloriosa superba, L. revealed strongest fibrinolytic activity followed by Sesbania grandiflora, L. Pers, Achyranthues aspera, L., Calotropis gigantean, R. Br., Mangifera indica, L., Ancardium occidentale, L. and Amaranthus gangeticus. Among the culinary spices Cuminum cyminum, L. revealed strong fibrinolytic potential followed by Terminalia chebula, Retz., Pimpinella anisum, Illicium verum , Nigella sativa, Linn, Mentha piperata and Myristica fragrans Houtt. The present study revealed the fibrinolytic potential of indigenous plants and culinary spices, to some extent optimistic pointing to the value of further studies in this field.
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