Androgenic alopecia, also known as male pattern baldness is hair loss that occurs due to an underlying susceptibility of hair follicles to androgenic miniaturization. Research studies revealed that environmental factors, hormonal imbalance and/or hereditary factors causes alopecia but many etiologies remain unknown. Treatment approach for androgenic alopecia are based on hair growth enhancement and reducing the progression of hair thinning. Other than allopathic medicines few herbal drugs over the decades has proved effective and fruitful results in combating alopecia. In the present study Seeds of Terminalia bellirica and rhizomes of Nardostachys jatamansi are evaluated for hair growth activity in androgen induced alopecia rat model. Petroleum ether extract of both plant at the dose of 2% and 5% was applied topically for evaluating their potential against alopecia. Alopecia was induced in albino rats by intramuscularly administration of testosterone for 20 days. Plant extract were simultaneously applied to inhibit the effect of androgen to develop alopecia. Finasteride was served as positive control. At the end of experiment growth of hair by visual inspection, follicular density by ocular micrometer and anagen/ telogen ratio by animal skin biopsy was investigated. Observed results revealed that both plant at 5% dose exhibited remarkable potential against androgen as evident by promising hair growth-promoting activity, follicular density and A/T ratio. Further studies are needed to isolate the biological active constituents and investigate the possible mechanism of action
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