Objectives.The identification of epidemiological factors increasing the risk of endometriosis could shorten the time to diagnosis.\nSpecific blood groups may be more common in patients with endometriosis. Study Design. We designed a cross-sectional study\nof 633 Caucasian women living in the same geographic area. Study group included 311 patients with histologically proven\nendometriosis. Control group included 322 patients without endometriosis as checked during surgery. Frequencies of ABO and\nRhesus groups in the study and control groups were compared using univariate and multivariate analyses. Results. We observed a\nhigher proportion of Rh-negativewomen in the study group, as compared to healthy controls.Multivariate analysis showed that Rhnegative\nwomen are twice as likely to develop endometriosis (aOR = 1.90; 95% CI: 1.20ââ?¬â??2.90). There was no significant difference\nin ABO group distribution between patients and controls. There was no difference when taking into account either the clinical\nforms (superficial endometriosis, endometrioma, and deep infiltration endometriosis) or the rAFS stages. Conclusion. Rh-negative\nwomen are twice as likely to develop endometriosis. Chromosome 1p, which contains the genes coding for the Rhesus, could also\nharbor endometriosis susceptibility genes.
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